Phenotype Image Detail

Image

Caption

Liver histology in mice with heterozygous and homozygous Fbxw7^tm1.1Iken mutations in combination with an oncogenic KrasG12D mutation. (A-C) Representative H&E staining of the livers of Fbxw7^tm1Iken/Fbxw7^tm1Iken;Kras^tm4Tyj/+ (A) and Fbxw7^tm1Iken/Fbxw7^tm1Iken;Kras^tm4Tyj/+; Fbxw7^tm1Iken/+ mice at the age of 8 months (B) and Fbxw7^tm1Iken Fbxw7^tm1Iken;Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺; Kras^tm4Tyj/Kras⁺ mice at the age of 8 weeks (C). Bar, 100 um.

Copyright

This image is from Ikenoue T, Sci Rep 2018 Jan 31;8(1):2021, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:258194

Associated Alleles

Symbol	Name
Fbxw7^tm1Iken	F-box and WD-40 domain protein 7; targeted mutation 1, Tsuneo Ikenoue
Kras^tm4Tyj	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson