Phenotype Image Detail

Image

Caption

Characterization of abnormal actin bundles (AABs) in Hspb7^tm1.2Chen/Hspb7^tm1.2Chen embryos. (A-C) Wild-type (WT) and mutant (KO) heart cryosections were stained with phalloidin (F actin) and antibodies against alpha-actinin (Actn2) and (A) E11.5: Myomesin (Myom), (B) E10.5: Tpm1, or (C) E10.5: cTnT. The locations of AABs or their relative positions are indicated by yellow arrows. High magnification views are shown as insets in corresponding images. Colors are depicted in merged images. DNA is stained with DAPI (blue). (Scale bar: A, 10 um; B and C, 5 um. Magnification: A, Insets, 3.3X; B and C, Insets, 2.2X.)

Copyright

This image is from Wu T, Proc Natl Acad Sci U S A 2017 Nov 7;114(45):11956-11961. Copyright 2017 National Academy of Sciences, U.S.A. J:256653

Associated Alleles

Symbol	Name
Hspb7^tm1.2Chen	heat shock protein family, member 7 (cardiovascular); targeted mutation 1.2, Ju Chen

Associated Genotypes

Allelic Composition	Genetic Background
Hspb7^tm1.2Chen/Hspb7^tm1.2Chen	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA