Phenotype Image Detail

Image

Caption

General phenotype of Hspb7^tm1.2Chen/Hspb7^tm1.2Chen embryos. (C) Whole-mount microscopic images of whole embryos (left lateral view) and embryonic hearts (anterior view) of wild-type (WT) and Hspb7^tm1.2Chen/Hspb7^tm1.2Chen (KO) embryos from E10.5 to E11.5. LV, left ventricle; OFT, outflow tract; RV, right ventricle. (Scale bar: 1 mm.) (D) Microscopic left lateral views of two (pairs 1 and 2) PECAM-stained E10.5 WT and KO embryos. High magnification views correspond to the dotted box in the whole-embryo images. CV, cardinal vein; LA, left atria; LV, left ventricle. (Scale bar: 1 mm.) (E) Hematoxylin and eosin (H&E) images of E10.5 WT and KO embryos acquired using NanoZoomer slide scanner. (Scale bar: 0.5 mm.) Estimated location of sectioning is indicated by a dotted line on the whole-mount embryo images to the left. (Scale bar: 1 mm.) Magnified right ventricle (RV; red box) and left ventricle (LV; green box) wall views are shown to the right. (Scale bars: 0.1 mm.)

Copyright

This image is from Wu T, Proc Natl Acad Sci U S A 2017 Nov 7;114(45):11956-11961. Copyright 2017 National Academy of Sciences, U.S.A. J:256653

Associated Alleles

Symbol	Name
Hspb7^tm1.2Chen	heat shock protein family, member 7 (cardiovascular); targeted mutation 1.2, Ju Chen

Associated Genotypes

Allelic Composition	Genetic Background
Hspb7^tm1.2Chen/Hspb7^tm1.2Chen	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA