About   Help   FAQ
Phenotype Image Detail
Image
Caption Ataxia, with circling movements and dargging of feet, in Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe mice (Tg1020). (A) Typical footprints from a healthy Tg(Prnp)a20Cwe/0 (tga20) mouse, showing regularly spaced tracks. (B) Same as A for an ataxic Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe (tg1020) mouse, showing circling movements and dragging of feet (arrows).
Copyright This image is from Sigurdson CJ, Proc Natl Acad Sci U S A 2009 Jan 6;106(1):304-9. Copyright 2009 National Academy of Sciences, U.S.A. J:143528
Associated
Alleles
Symbol Name
Prnptm1Cwe prion protein; targeted mutation 1, Charles Weissmann
Tg(Prnp)a20Cwe transgene insertion a20, Charles Weissmann
Tg(Prnp*S170N*N174T)1020Aag transgene insertion 1020, Adriano Aguzzi
Associated
Genotypes
Allelic Composition Genetic Background
Tg(Prnp)a20Cwe/0 Not Specified
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0 		involves: 129S7/SvEvBrd * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory