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Phenotype Image Detail
Image
Caption Sciatic nerve from a Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe (tg1020) mouse. (A) Semi-thin cross-section shows severe demyelinating lesions in the tg1020 mouse, and not in a Prnptm1Cwe/Prnptm1Cwe (Prnpo/o) mouse. (Band C) Ultrastructure of the sciatic nerve of a tg1020 mouse. (B) Onion bulb formation and macrophage (C) with vacuoles containing myelin debris (arrowheads) are seen.
Copyright This image is from Sigurdson CJ, Proc Natl Acad Sci U S A 2009 Jan 6;106(1):304-9. Copyright 2009 National Academy of Sciences, U.S.A. J:143528
Associated
Alleles
Symbol Name
Prnptm1Cwe prion protein; targeted mutation 1, Charles Weissmann
Tg(Prnp*S170N*N174T)1020Aag transgene insertion 1020, Adriano Aguzzi
Associated
Genotypes
Allelic Composition Genetic Background
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0 		involves: 129S7/SvEvBrd * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory