Phenotype Image Detail

Image

Caption

Absence of an endocardial/endothelial lineage in Etv2^{Gt(141.1H7)Cmhd}/Etv2^{Gt(141.1H7)Cmhd} heart and embryo. (Top) Morphological appearance of E8.5 wild-type (+/+, WT) and Etv2^{Gt(141.1H7)Cmhd}/Etv2^{Gt(141.1H7)Cmhd} (-/-) embryo littermates. Note that the whole-mount WT and null embryos are indistinguishable at E8.5. (Middle) Histological analyses of the WT and null embryo demonstrating an absence of the endocardial/endothelial lineage (End) and vasculature (PHV, primary heart vein; DA, dorsal aorta) in the null embryo compared to WT littermate. (Bottom) Immunohistochemical analysis of alpha-endomucin in the WT and null embryo further demonstrating an absence of the endocardial/endothelial lineage (arrowhead shown in WT) and an absence of the vasculature in the null embryo. A higher magnification field reveals an absence of endocardium in the null heart compared to the WT littermate (alpha-endomucin expressing endocardium indicated by an arrowhead).

Copyright

This image is from Ferdous A, Proc Natl Acad Sci U S A 2009 Jan 20;106(3):814-9. Copyright 2009 National Academy of Sciences, U.S.A. J:143866

Associated Alleles

Symbol	Name
Etv2^Gt(141.1H7)Cmhd	ets variant 2; gene trap 141.1H7, Centre for Modeling Human Disease

Associated Genotypes

Allelic Composition	Genetic Background
Etv2^Gt(141.1H7)Cmhd/Etv2^Gt(141.1H7)Cmhd	involves: 129S1/Sv * 129X1/SvJ