Phenotype Image Detail

Image

Caption

IL-21R deficiency prevents renal disease and mortality characteristic of BXSB-Yaa mice. (A and B) Kidney sections from 16-week-old Il21r^tm1Wjl/Il21r⁺ X/Yaa (Il21r+/-) and Il21r^tm1Wjl/Il21r^tm1Wjl X/Yaa (Il21-/-) mice were stained with H&E, periodic acid/Schiff reagent (PAS), or Masson's trichrome. (A) Representative sections. Kidneys of Il21r^tm1Wjl/Il21r⁺ X/Yaa (Il21r+/-) mice exhibited multiple pathological features, including a thickening of the glomerular basement membrane, perivascular inflammation associated with neutrophilic infiltrates, and focal adhesions with marked glomerular fibrosis, sclerosis, and Ig deposits. In contrast, kidneys from Il21r^tm1Wjl/Il21r^tm1Wjl X/Yaa (Il21-/-) mice were essentially free of all these abnormalities.

Copyright

This image is from Bubier JA, Proc Natl Acad Sci U S A 2009 Feb 3;106(5):1518-23. Copyright 2009 National Academy of Sciences, U.S.A. J:144484

Associated Alleles

Symbol	Name
Il21r^tm1Wjl	interleukin 21 receptor; targeted mutation 1, Warren J Leonard
Yaa	accelerated autoimmunity and lymphoproliferation transposition; accelerated autoimmunity and lymphoproliferation

Associated Genotypes

Allelic Composition	Genetic Background
Il21r^tm1Wjl/Il21r^tm1Wjl X/Yaa	BXSB.129(Cg)-Il21r^tm1Wjl/Dcr