Phenotype Image Detail

Image

Caption

Axoneme defects in Lrguk^Kaos/Lrguk^Kaos (Kaos/Kaos) mice. (A) The staining of testis sections with the axoneme marker, acetylated tubulin, indicated an almost complete absence of axoneme development in mutant germ cells. (B) Transmission electron microscopy indicating the absence of axoneme development in wild-type (WT/WT) and mutant elongating spermatids. Red arrows indicate outer dense fibers. Scale bar = 0.2 um. (C-D) Transmission electron microscopy of basal body docking to the plasma and nuclear membrane (C) and subsequent axoneme extension in WT cells but the absence of plasma membrane attachment and axoneme of extension in mutant spermatids. Scale bar = 2 um. (E) A closer examination of the early phases of basal body structure and movement revealed the presence of normal distal appendages (DAPs, green arrow) and sub-distal appendages (SAPs, red arrow) in WT cells associated with plasma membrane attachment. Mutant germ cells contained enlarged SAP and the basal body failed to associate with the plasma membrane. The scale bar = 2 um.

Copyright

This image is from Liu Y, PLoS Genet 2015 Mar;11(3):e1005090, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:222840

Associated Alleles

Symbol	Name
Lrguk^Kaos	leucine-rich repeats and guanylate kinase domain containing; kaos

Associated Genotypes

Allelic Composition	Genetic Background
Lrguk^Kaos/Lrguk^Kaos	involves: C57BL/6 * CBA