Phenotype Image Detail

Image

Caption

Loss of melanoblasts and differentiated melanocytes in whisker hair follicles of P38 Tg(Tyr-cre)1Lru/Y Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Dct-lacZ)A12Jkn/0 (TyrCre, yy1^f/f, Dct-LacZ) mice. XGal stain of whole-mount whiskers from P38 Tg(Tyr-cre)1Lru/Y Yy1^tm2.1Yshi/Yy1⁺ Tg(Dct-lacZ)A12Jkn/0 (TyrCre, yy1^f/+, Dct-LacZ) and TyrCre, yy1^f/f, Dct-LacZ mice. The distribution of Dct-LacZ+ melanocyte stem cells (melanoblasts) is indicated by double arrow.

Copyright

This image is from Li J, PLoS Genet 2012 May;8(5):e1002688, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185128

Associated Alleles

Symbol	Name
Tg(Dct-lacZ)A12Jkn	transgene insertion A12, Ian Jackson
Tg(Tyr-cre)1Lru	transgene insertion 1, Lionel Larue
Yy1^tm2.1Yshi	YY1 transcription factor; targeted mutation 2.1, Yang Shi

Associated Genotypes

Allelic Composition	Genetic Background
Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * CBA * DBA/2