Phenotype Image Detail

Image

Caption

Topical treatment with tamoxifen for 14 days induces skin hyperpigmentation on the ear of Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0 mice. Fontana-Masson staining shows increased epidermal thickness and melanin content in the epidermis. (C) Topical treatment with tamoxifen for 14 days induces skin hyperpigmentation on the tail. TRP1 staining highlights the increased number of melanocytes in the tail epidermis. Quantitation of melanocyte staining shows that the number of dermal melanocytes was not significantly changed.

Copyright

This image is from Chang CH, Proc Natl Acad Sci U S A 2017 Sep 19;114(38):E8035-E8044. Copyright 2017 National Academy of Sciences, U.S.A. J:253611

Associated Alleles

Symbol	Name
Csnk1a1^tm1.1Ybn	casein kinase 1, alpha 1; targeted mutation 1.1, Yinon Ben-Neriah
Tg(KRT14-cre/ERT)20Efu	transgene insertion 20, Elaine Fuchs

Associated Genotypes

Allelic Composition	Genetic Background
Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0	involves: 129S1/Sv * 129X1/SvJ * CD-1