Phenotype Image Detail

Image

Caption

B) Swelling of the tail, an acute type of sunburn damage, is observed in Csnk1a1^tm1.1Ybn/Csnk1a1⁺ Tg(KRT14-cre/ERT)20Efu/0 heterozygous mice after the sunburn dose of UVB exposure, whereas the eumelanized tails of Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(KRT14-cre/ERT)20Efu (SKO) mice have a normal diameter. TUNEL staining demonstrated that the UVB exposure induced many sunburn cells (apoptotic cells) in the skin of heterozygous mice but induced many fewer apoptotic cells in SKO mice.

Copyright

This image is from Chang CH, Proc Natl Acad Sci U S A 2017 Sep 19;114(38):E8035-E8044. Copyright 2017 National Academy of Sciences, U.S.A. J:253611

Associated Alleles

Symbol	Name
Csnk1a1^tm1.1Ybn	casein kinase 1, alpha 1; targeted mutation 1.1, Yinon Ben-Neriah
Tg(KRT14-cre/ERT)20Efu	transgene insertion 20, Elaine Fuchs

Associated Genotypes

Allelic Composition	Genetic Background
Csnk1a1^tm1.1Ybn/Csnk1a1^tm1.1Ybn Tg(KRT14-cre/ERT)20Efu/0	involves: 129S1/Sv * 129X1/SvJ * CD-1