Phenotype Image Detail

Image

Caption

Loss of melanocyte stem cells (MSCs) in Tg(Tyr-cre)#Lru/0 Rbpj^tm1Hon/Rbpj^tm1Hon (Tyr-Cre;RBP-J^f/f) mice. Skin sections from P4 (C-F), P12 (G-J), and P32 (K-N) Tg(Tyr-cre)#Lru/0 Rbpj^tm1Hon/Rbpj⁺ (Tyr-Cre;RBP-J^+/f) mice (C, D, G, H, K, and L) and Tg(Tyr-cre)#Lru/0 Rbpj^tm1Hon/Rbpj^tm1Hon mice (E, F, I, J, M, and N) were immunostained using anti-Dct antibody (green). Whole hair follicle (HF) images (C, E, G, and I), lower permanent portion (LPP) of HF images (D, F, H, J, L, and N), and hair matrix (HM) images (K and M) are shown. Note that Dct+ melanoblasts (Mbs) at the LPP of a HF exist at P4 (E and F) but have essentially disappeared at P12 (I and J), whereas mature melanocytes (MCs) at the HM retain in Tg(Tyr-cre)#Lru/0 Rbpj^tm1Hon/Rbpj^tm1Hon mice (I). Arrowheads indicate Mbs at the LPP of the HF, and arrows indicate MCs at the HM.

Copyright

This image is from Moriyama M, J Cell Biol 2006 May 8;173(3):333-9, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:111228

Associated Alleles

Symbol	Name
Rbpj^tm1Hon	recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Tasuku Honjo
Tg(Tyr-cre)#Lru	transgene insertion, Lionel Larue

Associated Genotypes

Allelic Composition	Genetic Background
Rbpj^tm1Hon/Rbpj^tm1Hon Tg(Tyr-cre)#Lru/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2