Phenotype Image Detail

Image

Caption

Loss of Ube3b results in growth retardation. (A) Ube3b^{tm1a(EUCOMM)Hmgu}/Ube3b^{tm1a(EUCOMM)Hmgu} knockout (KO) mice show significant reduction in weight and length versus wild-type (WT) or heterozygous (Het) mice (weight: ***P<0.0001, two-way ANOVA; n = 5-18 WT, 7-37 Het, 5-12 KO; nose-to-rump length: ***P = 0.0003, one-way ANOVA; n = 9 WT, 10 Het, 9 KO).

Copyright

This image is from Cheon S, Proc Natl Acad Sci U S A 2019 Feb 26;116(9):3662-3667. Copyright 2019 National Academy of Sciences, U.S.A. J:273879

Associated Alleles

Symbol	Name
Ube3b^tm1a(EUCOMM)Hmgu	ubiquitin protein ligase E3B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Ube3b^tm1a(EUCOMM)Hmgu	ubiquitin protein ligase E3B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH

Associated Genotypes

Allelic Composition	Genetic Background
Ube3b^tm1a(EUCOMM)Hmgu/Ube3b^tm1a(EUCOMM)Hmgu	C57BL/6-Ube3b^tm1a(EUCOMM)Hmgu