Phenotype Image Detail

Image

Caption

Golgi-Cox staining shows significantly reduced dendritic complexity, length, and spine density in neurons from the caudal and rostral cortex of Ube3b^{tm1a(EUCOMM)Hmgu}/Ube3b^{tm1a(EUCOMM)Hmgu} (KO) versus wild-type (WT). Data were obtained from basal dendrites of cortical layer II/III neurons (caudal: *P = 0.0235, **P = 0.0029, ***P < 0.0001; rostral: *P = 0.0355, **P = 0.0057, ***P = 0.0029; n = 13-15 WT, 10-15 KO). (C, Left) Representative tracings of Golgi-Cox-stained cortical layer II/III neurons and (C, Right) of their dendritic segments. (Scale bars, 5 um.)

Copyright

This image is from Cheon S, Proc Natl Acad Sci U S A 2019 Feb 26;116(9):3662-3667. Copyright 2019 National Academy of Sciences, U.S.A. J:273879

Associated Alleles

Symbol	Name
Ube3b^tm1a(EUCOMM)Hmgu	ubiquitin protein ligase E3B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Ube3b^tm1a(EUCOMM)Hmgu	ubiquitin protein ligase E3B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH

Associated Genotypes

Allelic Composition	Genetic Background
Ube3b^tm1a(EUCOMM)Hmgu/Ube3b^tm1a(EUCOMM)Hmgu	C57BL/6-Ube3b^tm1a(EUCOMM)Hmgu