Phenotype Image Detail

Image

Caption

Neuroanatomical abnormalities in the Ube3b^{tm1a(EUCOMM)Hmgu}/Ube3b^{tm1a(EUCOMM)Hmgu} (KO) mice. Nissl staining of brains from mutant (KO) and wild-type (WT) mice revealed a hypoplastic corpus callosum, enlarged ventricles, and decreased thickness of the primary somatosensory cortex in the KO compared to WT. The thickness of the primary motor cortex was not different. Representative images of Nissl stained brains (A). (corpus callosum area: *P=0.0153, ventricle area: *P=0.0196, thickness of the somatosensory cortex: *P=0.0376, n=3 WT, 3 KO). Scale bars, 500 um.

Copyright

This image is from Cheon S, Proc Natl Acad Sci U S A 2019 Feb 26;116(9):3662-3667. Copyright 2019 National Academy of Sciences, U.S.A. J:273879

Associated Alleles

Symbol	Name
Ube3b^tm1a(EUCOMM)Hmgu	ubiquitin protein ligase E3B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Ube3b^tm1a(EUCOMM)Hmgu	ubiquitin protein ligase E3B; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH

Associated Genotypes

Allelic Composition	Genetic Background
Ube3b^tm1a(EUCOMM)Hmgu/Ube3b^tm1a(EUCOMM)Hmgu	C57BL/6-Ube3b^tm1a(EUCOMM)Hmgu