Phenotype Image Detail

Image

Caption

Angpt1 is critical in early vascular development. Simplification of the cardiac trabeculation pattern of E10.5 Angpt1^tm1.2Seq/Angpt1^tm1.2Seq Kdr^tm2.1Jrt/Kdr⁺ embryos as shown by immunohistochemistry for (A) Ng2 (scale bar: 100 um) and (B) Desmin (scale bar: 100 um). (C) Dissection microscope photos show that the mutant embryos are markedly growth restricted at E10.5 and have disorganized vasculature as evident in embryos carrying a Kdr-GFP transgene reporter (Kdr^tm2.1Jrt) (scale bar: 1 mm).

Copyright

This image is from Jeansson M, J Clin Invest 2011 Jun 1;121(6):2278-89 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:174022

Associated Alleles

Symbol	Name
Angpt1^tm1.2Seq	angiopoietin 1; targeted mutation 1.2, Susan E Quaggin
Kdr^tm2.1Jrt	kinase insert domain protein receptor; targeted mutation 2.1, Janet Rossant

Associated Genotypes

Allelic Composition	Genetic Background
Angpt1^tm1.2Seq/Angpt1^tm1.2Seq Kdr^tm2.1Jrt/Kdr^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL