Phenotype Image Detail

Image

Caption

Angpt1 is critical in cardiac development. 3D optical projection tomography (OPT) data showing surface rendering of the vasculature stained with CD31 in E10.5 control (Angpt1^del/+) and Angpt1^tm1.2Seq/Angpt1^tm1.2Seq Kdr^tm2.1Jrt/Kdr⁺ (Angpt1^del/del) embryos. Shown are views from (A-B) behind, (D-E) the side, and (G-H) enlargement of the right half of the head. (J-K) Embryo sections of autofluorescence, (M-N) with an enlargement of the heart in Angpt1^del/del embryos. By E10.5, mutant embryos exhibit widespread vascular defects, with fusion of vessels with larger diameters and absence of patterning. Scale bar: 500 um.

Copyright

This image is from Jeansson M, J Clin Invest 2011 Jun 1;121(6):2278-89 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:174022

Associated Alleles

Symbol	Name
Angpt1^tm1.2Seq	angiopoietin 1; targeted mutation 1.2, Susan E Quaggin
Kdr^tm2.1Jrt	kinase insert domain protein receptor; targeted mutation 2.1, Janet Rossant

Associated Genotypes

Allelic Composition	Genetic Background
Angpt1^tm1.2Seq/Angpt1^tm1.2Seq Kdr^tm2.1Jrt/Kdr^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL