Phenotype Image Detail

Image

Caption

Toluidine blue/pyronin g stained semi-thin sections reveal cystic spaces in white matter of Gjc2^tm2.1Kwi/Gjc2^tm2.1Kwi (Cx47^M282T/M282T) mice. Semi-thin sections of cerebellar white matter of wild-type (Cx47^+/+) (A, C) heterozygous (Cx47^+/M282T) (B, E, I) and homozygous mutant (Cx47^M282T/M282T) (C, F, G, J) mice are shown after staining with toluidine blue/pyronin g. Cystic spaces in white matter are indicated by asterisks in C and can be delineated from blood vessels (BV) due to their irregular lining and absence of endothelia. At higher magnification (F, G) cysts can be shown to contain cellular debris (arrows in G). No alterations were seen in cerebella from heterozygous mice (B, E). In the prechiasmatic optic fascicle of homozygous mutant mice, similar cysts are evident (arrows in J, compared to blood vessles (BV) in the WT control shown in H). Scale bars: A-C, 50 um; DJ, 20 um.

Copyright

This image is from Tress O, PLoS Genet 2011 Jul;7(7):e1002146, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:174197

Associated Alleles

Symbol	Name
Gjc2^tm2.1Kwi	gap junction protein, gamma 2; targeted mutation 2.1, Klaus Willecke

Associated Genotypes

Allelic Composition	Genetic Background
Gjc2^tm2.1Kwi/Gjc2^tm2.1Kwi	involves: C57BL/6 * SJL