Phenotype Image Detail

Image

Caption

A variable number of blood vessels predominantly in the hippocampal region of Gjc2^tm2.1Kwi/Gjc2^tm2.1Kwi (Cx47^M282T/M282T) mice feature perivascular glia being filled with basophilic material or undergoing conspicuous destruction (wild-type, shown in A, C; homozygous mutant in D and E, arrows pointing to glia cells). Additionally, scattered neurons within the pyramidal cell layer show similar degenerative changes (WT in A, homozygous mutant in B). Scale bars: A-C, 20 um; D and E, 10 um.

Copyright

This image is from Tress O, PLoS Genet 2011 Jul;7(7):e1002146, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:174197

Associated Alleles

Symbol	Name
Gjc2^tm2.1Kwi	gap junction protein, gamma 2; targeted mutation 2.1, Klaus Willecke

Associated Genotypes

Allelic Composition	Genetic Background
Gjc2^tm2.1Kwi/Gjc2^tm2.1Kwi	involves: C57BL/6 * SJL