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Caption | Morphology and composition of intestinal crypts in Cdc25atm1Hpw/Cdc25atm1.1Hpw Cdc25btm1Pjd/Cdc25btm1Pjd Cdc25ctm1Hpw/Cdc25ctm1Hpw Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ (TKO) mice. (A-D) Intestinal sections were stained with PAS/Alcian blue to label Paneth cells and goblet cells. Sections from wild-type (WT) (A) and TKO (B-D) mice are shown. The inset in (B) is magnified in (C). In (A), asterisks indicate CBC cells. In (D), asterisks indicate immature Paneth cells. Crypt borders are indicated with black hatched line. (Scale bar: 10 um.) (E and F) Intestinal sections were stained with the enterocyte-specific marker L-Fabp. Sections from WT (E) and TKO (F) mice are shown. Green, L-Fabp; blue, nuclei (DAPI). Hatched lines denote crypt margins. (Scale bar: 100 um.) (G) Musashi-1 and Dcamkl-1-positive cells are maintained in TKO mice. Green (Upper), Musashi-1; green (Lower), Dcamkl-1; red, BrdU; blue, DAPI. (Scale bars: 20 um.) Crypt borders are outlined. Arrows indicate cells staining negative for BrdU but positive for Musashi-1 or Dcamkl-1. (H) The number and location of 28 Mushashi-1-positive cells were determined in TKO mice. The cell at the base of the crypt was defined as position 1. | ||||||||||||
Copyright | This image is from Lee G, Proc Natl Acad Sci U S A 2009 Mar 24;106(12):4701-6. Copyright 2009 National Academy of Sciences, U.S.A. J:145768 | ||||||||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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