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Caption | Enhanced Wnt signaling and differentiation in crypts of Cdc25atm1Hpw/Cdc25atm1.1Hpw Cdc25btm1Pjd/Cdc25btm1Pjd Cdc25ctm1Hpw/Cdc25ctm1Hpw Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ (TKO) mice. (A and B) Tissue sections of small intestines prepared from wild-type (WT) (A) and TKO (B) mice were stained with antibodies specific for Beta-catenin (green) and lysozyme (red). Nuclei were stained with DAPI (blue). Arrows indicate cells staining positive for nuclear Beta-catenin. (Scale bar: 10 um.) (C-G) Small intestines were dissected and processed for transmission electron microscopy. (D) An EM section of crypt from a WT mouse and higher magnification (C) showing a CBC cell between 2 mature Paneth cells, marked with an asterisk in (D). (E) EM sections of crypt from a TKO mouse. The inset in (E) is shown at higher magnification in (F). The arrow indicates an immature goblet cell with characteristic apical mucinogenic granules. In (F), a cell with stem-like morphology above the Paneth cell compartment is marked with an asterisk. (G) CBC cells differentiated along the Paneth cell lineage as marked by the appearance of small, electron-dense secretory granules. In (G), asterisks indicate the position of the intestinal lumen. [Scale bar: 10 um (D and E); 2 um (F and G).] | ||||||||||||
Copyright | This image is from Lee G, Proc Natl Acad Sci U S A 2009 Mar 24;106(12):4701-6. Copyright 2009 National Academy of Sciences, U.S.A. J:145768 | ||||||||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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