Phenotype Image Detail

Image

Caption

Crypts are smaller and sparser in the Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺ (TKO) mice than in the control (BCKO) mice. Crypt sizes were calculated by counting pixels occupied by a single crypt in randomly chosen microscopic fields along the proximal-distal axis of the small intestine. The crypts of TKO mice were calculated to be ~50% smaller than those in control mice.

Copyright

This image is from Lee G, Proc Natl Acad Sci U S A 2009 Mar 24;106(12):4701-6. Copyright 2009 National Academy of Sciences, U.S.A. J:145768

Associated Alleles

Symbol	Name
Cdc25a^tm1.1Hpw	cell division cycle 25A; targeted mutation 1, Helen Piwnica-Worms
Cdc25a^tm1Hpw	cell division cycle 25A; targeted mutation 1, Helen Piwnica-Worms
Cdc25b^tm1Pjd	cell division cycle 25B; targeted mutation 1, Peter J Donovan
Cdc25c^tm1Hpw	cell division cycle 25C; targeted mutation 1, Helen Piwnica-Worms
Gt(ROSA)26Sor^tm1(cre/ERT)Brn	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Anton Berns

Associated Genotypes

Allelic Composition	Genetic Background
Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Gt(ROSA)26Sor^tm1(cre/ERT)Brn/Gt(ROSA)26Sor^+	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6