Phenotype Image Detail

Image

Caption

Histology and immunophenotyping of mammary carcinomas in Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺ mice. (A) Kras*-induced mouse mammary tumors exhibit 4 histopathological forms. The insets in the H&E-stained sections in the top row show carcinoma in situs (CISs) of the corresponding invasive carcinomas. (B) Examples of mouse and human pale breast cancers. A mouse Kras*-induced pale cell carcinoma exhibits a strong histological similarity (H&E staining) with a specimen of human atypical medullary breast cancer, and both tumor types are strongly positive for Igf1r immunostaining. (C) KRAS copy gains in some atypical medullary breast cancers with pale cells. The dual-color FISH analysis using KRAS (red) and chromosome 12 centromeric (green) probes shows that in cells from 3 different human pale breast cancer specimens (the right panels are from the same tumor), there are copy gains of the 12p12.1 region (up to 6 KRAS copies). (Magnification: A, A Insets, B, 400X; C, 1,000X.)

Copyright

This image is from Klinakis A, Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2359-64. Copyright 2009 National Academy of Sciences, U.S.A. J:146290

Associated Alleles

Symbol	Name
Eef1a1^tm1(Kras*)Arge	eukaryotic translation elongation factor 1 alpha 1; targeted mutation 1, Argiris Efstratiadis
Wap^tm1(cre)Arge	whey acidic protein; targeted mutation 1, Argiris Efstratiadis

Associated Genotypes

Allelic Composition	Genetic Background
Eef1a1^tm1(Kras*)Arge/Eef1a1^+ Wap^tm1(cre)Arge/Wap^+	involves: 129S1/Sv