Phenotype Image Detail

Image

Caption

Renal damage in Nphs2^tm2.1Antc/Nphs2^tm3.1Antc Tg(CAG-cre/Esr1*)86Lbgn/0 mice. (A) control, (B) week 2, (C) week 4, (D) week 12. Mice develop significant tubular atrophy and severe interstitial fibrosis, which are visible from the first week after induction.

Copyright

This image is from Tabatabaeifar M, PLoS One 2017;12(10):e0186574, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:245693

Associated Alleles

Symbol	Name
Nphs2^tm2.1Antc	nephrosis 2, podocin; targeted mutation 2.1, Corinne Antignac
Nphs2^tm3.1Antc	nephrosis 2, podocin; targeted mutation 3.1, Corinne Antignac
Tg(CAG-cre/Esr1*)86Lbgn	transgene insertion 86, Laurence Bugeon

Associated Genotypes

Allelic Composition	Genetic Background
Nphs2^tm2.1Antc/Nphs2^tm3.1Antc Tg(CAG-cre/Esr1*)86Lbgn/0	involves: 129S2/SvPas * C57BL/6 * DBA