Phenotype Image Detail

Image

Caption

Mononuclear cell infiltration of the large intestines and salivary glands are reduced in Mertk^tm1Gkm/Mertk^tm1Gkm (Mer^KD/KD) mice. (A) Five-uM sections of large intestine tissue were prepared from formalin-fixed, parafin-embedded samples taken from 3 mice/group and H&E stained. A minimum of 5 nonoverlapping sections per mouse were examined and mononuclear cell infiltrates (black arrows) scored from 0 to 4. *, P = 0.03. (B) Five-uM sections of salivary gland tissue were prepared from formalin-fixed, paraffin-embedded samples from 3 mice/group and H&E stained. A minimum of 10 nonoverlapping sections were examined and the number of focal infiltrates (black arrows) per section recorded. +, P = 0.004.

Copyright

This image is from Wallet MA, Proc Natl Acad Sci U S A 2009 Mar 24;106(12):4810-5. Copyright 2009 National Academy of Sciences, U.S.A. J:147153

Associated Alleles

Symbol	Name
Mertk^tm1Gkm	MER proto-oncogene tyrosine kinase; targeted mutation 1, Glenn K Matsushima

Associated Genotypes

Allelic Composition	Genetic Background
Mertk^tm1Gkm/Mertk^tm1Gkm	NOD.129P2-Mertk^tm1Gkm