Phenotype Image Detail

Image

Caption

In situ BrdU incorporation was evaluated for embryos at E13.5 (lens) or E16.5 (zones of proliferative and flattened cells in the humerus) in wild-type (p57^WT), Cdkn1c^tm1Kat/Cdkn1c⁺ (p57^KO), and Cdkn1c^{tm1.1(Cdkn1b*)Kei}/Cdkn1c⁺ (p57^p27KI) mice. BrdU-positive cells, as well as nuclei stained with Hoechst 33258 (lens only) are green and gray, respectively. Arrowheads indicate ectopic BrdU-labeled cells in the posterior chamber of the lens. (Scale bar, 50 um.)

Copyright

This image is from Susaki E, Proc Natl Acad Sci U S A 2009 Mar 31;106(13):5192-7. Copyright 2009 National Academy of Sciences, U.S.A. J:147145

Associated Alleles

Symbol	Name
Cdkn1c^tm1.1(Cdkn1b*)Kei	cyclin dependent kinase inhibitor 1C; targeted mutation 1.1, Keiichi I Nakayama
Cdkn1c^tm1Kat	cyclin dependent kinase inhibitor 1C; targeted mutation 1, Katsuhiko Takahashi

Associated Genotypes

Allelic Composition	Genetic Background
Cdkn1c^tm1.1(Cdkn1b*)Kei/Cdkn1c^+	involves: 129P2/OlaHsd * C57BL/6J
Cdkn1c^tm1Kat/Cdkn1c^+	involves: 129P2/OlaHsd * C57BL/6J