Phenotype Image Detail

Image

Caption

Tissue-specific residual phenotypes of Cdkn1c^tm1Kat/Cdkn1c⁺ (p57^KO) and Cdkn1c^{tm1.1(Cdkn1b*)Kei}/Cdkn1c⁺ (p57^p27KI) mice. (A and B) Representative histopathology of the renal papilla and placenta, respectively, of E18.5 embryos of the indicated genotypes. Hematoxylin-eosin staining shows developmental defects in the renal papilla (arrowheads), and necrosis in the placenta of p57^KO and p57^p27KI mice. (Scale bar, 200 um.) (C) Representative histopathology of the umbilical region (Upper), and the tip of the rectus abdominis muscle (Lower) of P0 embryos. Arrows indicate the distance between the umbilicus and the tip of the rectus abdominis muscle (U-M distance) (Upper), and the thickness of the muscle layer at a position 100 um from the tip (Lower). Hematoxylin-eosin staining reveals an increased U-M distance and thinner muscle layer in both p57^KO and p57^p27KI mice. (Scale bars: for Upper, 200 um; for Lower, 50 um.)

Copyright

This image is from Susaki E, Proc Natl Acad Sci U S A 2009 Mar 31;106(13):5192-7. Copyright 2009 National Academy of Sciences, U.S.A. J:147145

Associated Alleles

Symbol	Name
Cdkn1c^tm1.1(Cdkn1b*)Kei	cyclin dependent kinase inhibitor 1C; targeted mutation 1.1, Keiichi I Nakayama
Cdkn1c^tm1Kat	cyclin dependent kinase inhibitor 1C; targeted mutation 1, Katsuhiko Takahashi

Associated Genotypes

Allelic Composition	Genetic Background
Cdkn1c^tm1.1(Cdkn1b*)Kei/Cdkn1c^+	involves: 129P2/OlaHsd * C57BL/6J
Cdkn1c^tm1Kat/Cdkn1c^+	involves: 129P2/OlaHsd * C57BL/6J