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Phenotype Image Detail
Image
Caption Dioxin-induced hepatic injury in Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn (Cyp1a1-/-) and Cyp1a2tm1Dwn/Cyp1a2tm1Dwn (Cyp1a2-/-) mice. (B and C) Liver sections stained with H&E and immunostained with F4/80 antibody. (B) H&E. The black arrowhead indicates the region of hydropic degeneration; * indicates focal inflammation. (Magnification: X100.) (C) F4/80. The brown spots indicate F4/80-positive cells. (Magnification: X100.)
Copyright This image is from Nukaya M, Proc Natl Acad Sci U S A 2009 Mar 24;106(12):4923-8. Copyright 2009 National Academy of Sciences, U.S.A. J:147150
Associated
Alleles
Symbol Name
Cyp1a1tm1.1Dwn cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 1.1, Daniel W Nebert
Cyp1a2tm1Dwn cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 1, Daniel W Nebert
Associated
Genotypes
Allelic Composition Genetic Background
Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn B6.129P2-Cyp1a1tm1.1Dwn
Cyp1a2tm1Dwn/Cyp1a2tm1Dwn B6.129P2-Cyp1a2tm1Dwn
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory