Phenotype Image Detail

Image

Caption

Accumulation of clathrin-coated vesicles (CCVs) and clathrin cages at Dnajc6^tm1Legr/Dnajc6^tm1Legr (KO) synapses from deep cerebellar nuclei of adult mice as revealed by electron microscopy. (A) Representative example of a wild-type (WT) synapse. A clathrin-coated structure is indicated by the circle. (B) Percentage of CCVs/cages (assembled clathrin structures, (CSs) relative to synaptic vesicles (SVs) at WT and knockout synapses. (C and D) Examples of KO synapses where a variable number of CCVs or empty cages can be seen. Typically, CCVs/cages (asterisks indicate areas enriched in these structures) are located at the periphery of synaptic vesicle clusters (such clusters are delineated by dotted lines in the figures) and often along the plasma membrane. The insets in C and D are high-magnification views of the rectangular regions that show empty cages and CCVs, respectively. (Scale bars, 200 nm.)

Copyright

This image is from Yim YI, Proc Natl Acad Sci U S A 2010 Mar 2;107(9):4412-7. Copyright 2010 National Academy of Sciences, U.S.A. J:158574

Associated Alleles

Symbol	Name
Dnajc6^tm1Legr	DnaJ heat shock protein family (Hsp40) member C6; targeted mutation 1, Lois Greene

Associated Genotypes

Allelic Composition	Genetic Background
Dnajc6^tm1Legr/Dnajc6^tm1Legr	B6.129-Dnajc6^tm1Legr