Phenotype Image Detail

Image

Caption

Spindle dysmorphogenesis in embryos from Khdc3^tm1Dean/Khdc3^tm1Dean females. (A) Immunofluorescence of delayed embryos recovered from Khdc3^tm1Dean/Khdc3^tm1Dean mutant females at E2.5 showing a high incidence of abnormal spindles, including 1-polar (arrows), 3-polar (arrows), broad spindles (brackets), and irregular shapes (asterisks). (B) Time-lapse images showing spindle formation and movement in embryos from normal and mutant females after microinjection with GFP-Beta5 tubulin mRNA. The time points of the nuclear envelop breakdown were set at 0 min.

Copyright

This image is from Zheng P, Proc Natl Acad Sci U S A 2009 May 5;106(18):7473-8. Copyright 2009 National Academy of Sciences, U.S.A. J:148330

Associated Alleles

Symbol	Name
Khdc3^tm1Dean	KH domain containing 3, subcortical maternal complex member; targeted mutation 1, Jurrien Dean

Associated Genotypes

Allelic Composition	Genetic Background
Khdc3^tm1Dean/Khdc3^tm1Dean	involves: 129/Sv * C57BL/6