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Phenotype Image Detail
Image
Caption Inactivation of the spindle assembly checkpoint (SAC) in embryos from Khdc3tm1Dean/Khdc3tm1Dean females. (A) Metaphase with misaligned chromosomes (arrow) in delayed embryos from Khdc3tm1Dean/Khdc3tm1Dean mutant females. (B) Same as (A) showing lagging chromosomes (arrows) at the onset of anaphase. (C) MAD2 required for the SAC was located on kinetochores (arrows) of normal embryos, but was not detected on kinetochores of delayed embryos from mutant females.
Copyright This image is from Zheng P, Proc Natl Acad Sci U S A 2009 May 5;106(18):7473-8. Copyright 2009 National Academy of Sciences, U.S.A. J:148330
Associated
Alleles
Symbol Name
Khdc3tm1Dean KH domain containing 3, subcortical maternal complex member; targeted mutation 1, Jurrien Dean
Associated
Genotypes
Allelic Composition Genetic Background
Khdc3tm1Dean/Khdc3tm1Dean involves: 129/Sv * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory