Phenotype Image Detail

Image

Caption

Ataxic behavior in Trpc3^Mwk/Trpc3⁺ (Mwk/+) mice. (A) Representative footprint patterns of wild-type (WT) and mutant mice at 2 months. Footprint patterns were quantitatively assessed for gait width (B) and step alternation uniformity (C). Mutant mice displayed significantly wider gait (33 +/- 2 mm vs. 27 +/- 1 mm) and irregular step alternation (alternation coefficient 0.36 +/- 0.035 vs. 0.24 +/- 0.02) compared with WT controls (mean +/- SEM, n = 8, P < 0.05, ANOVA followed by Fisher's PLSD post hoc test). (D) Static rod performance of WT and mutant mice at 2 months. Mutant mice were significantly impaired in their ability to walk across the beam (35.7 +/-13.25 sec vs. 180 +/- 0 sec; mean +/- SEM, n = 8, P < 0.0001, ANOVA followed by Fisher's PLSD post hoc test).

Copyright

This image is from Becker EB, Proc Natl Acad Sci U S A 2009 Apr 21;106(16):6706-11. Copyright 2009 National Academy of Sciences, U.S.A. J:148340

Associated Alleles

Symbol	Name
Trpc3^Mwk	transient receptor potential cation channel, subfamily C, member 3; moonwalker

Associated Genotypes

Allelic Composition	Genetic Background
Trpc3^Mwk/Trpc3^+	involves: BALB/cAnN * C3H/HeH