Phenotype Image Detail

Image

Caption

Testis histology of wild-type (Rxfp2^+/+, WT), heterozygous Rxfp2^m1Lja/Rxfp2⁺ (Rxfp2^+/DG), and Rxfp2^m1Lja/Rxfp2^m1Lja (Rxfp2^DG/DG) mice stained with hematoxylin and eosin. A, D) WT testes are a normal size and have ongoing spermatogenesis within the seminiferous tubules. B, E) Heterozygous testes also demonstrate appropriate size and spermatogenesis. C) Homozygous mutant testes are small compared to those of WT and heterozygous littermates. F) Spermatogenesis within homozygous mutant testes demonstrates defects ranging from germ cell loss to a Sertoli-cell-only phenotype.

Copyright

This image is from Harris RM, Mamm Genome 2010 Oct;21(9-10):442-9 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:166053

Associated Alleles

Symbol	Name
Rxfp2^m1Lja	relaxin/insulin-like family peptide receptor 2; mutation 1, J Larry Jameson

Associated Genotypes

Allelic Composition	Genetic Background
Rxfp2^m1Lja/Rxfp2^m1Lja	C57BL/6J-Rxfp2^m1Lja