Phenotype Image Detail

Image

Caption

Cd300lb^tm1Toki/Cd300lb^tm1Toki mice were protected from renal ischemia reperfusion injury (IRI). 6(C and D) Tubular injury (C) or neutrophil accumulation within the interstitium in IRI kidneys (D) of wild-type (WT) and mutant mice at 24 h after surgery. Representative sections of the outer and inner medulla from contralateral or IRI kidneys from WT and mutant mice at 24 h after surgery. (C) Hematoxylin and eosin staining. Bars, 100 um. (D) Immunohistochemical identification of neutrophils (brown) in the outer and inner medulla (top and bottom, respectively). Immunohistochemical identification of neutrophils (green) in the outer medulla (middle). The nuclei were counterstained with DAPI (blue). Bars, 100 um. (E) Neutrophil counts of 10 high-power fields (HPFs) from each section from the outer medulla. Data shown are means SD (n = 8 mice in each group). Statistically significant differences are shown. *, P<0.05. Three independent experiments were performed in C, D & E.

Copyright

This image is from Yamanishi Y, J Exp Med 2010 Jul 5;207(7):1501-11, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:163402

Associated Alleles

Symbol	Name
Cd300lb^tm1Toki	CD300 molecule like family member B; targeted mutation 1, Toshio Kitamura

Associated Genotypes

Allelic Composition	Genetic Background
Cd300lb^tm1Toki/Cd300lb^tm1Toki	B6.Cg-Cd300lb^tm1Toki