Phenotype Image Detail

Image

Caption

IL-33 is involved in the induction of inflammation during DSS-induced colitis. Colon sections (A) (hematoxylin-eosin, 100X. Representative data from three to five mice are shown), score of the severity of colitis (B) (only inflamed sites were evaluated on day 15), and the levels of MPO activity (C) in colon homogenates from wild-type (IL-33+/+) and Il33^tm1Snak/Il33^tm1Snak (IL-33-/-) mice on day 8 or 15 during 3.0% DSS-induced colitis or in naive mice. Data show the mean + SE: *P < 0.05 vs. corresponding values for naive mice; P < 0.05 vs. corresponding values for wild-type mice.

Copyright

This image is from Oboki K, Proc Natl Acad Sci U S A 2010 Oct 26;107(43):18581-6. Copyright 2010 National Academy of Sciences, U.S.A. J:165513

Associated Alleles

Symbol	Name
Il33^tm1Snak	interleukin 33; targeted mutation 1, Susumu Nakae

Associated Genotypes

Allelic Composition	Genetic Background
Il33^tm1Snak/Il33^tm1Snak	involves: C57BL/6 * CBA