Phenotype Image Detail

Image

Caption

Defects of cardiac mitochondria and mitochondrion-associated membranes in Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte}/Gt(ROSA)26Sor⁺ (taz-deficient) mice. A and B, representative electron micrographs of longitudinal sections of cardiac ventricular muscle of 8-month-old non-transgenic (NTG) (A) and taz-deficient (B) mice. C and D, representative micrographs of deteriorating mitochondria in ventricular (C) and atrial (D) muscle from taz-deficient hearts. White arrows in C and K point to mitochondria undergoing mitophagy. Mitochondria with large central vacuoles are abundantly observed in taz-deficient cardiomyocytes (black arrowhead in D). Mitochondrion-associated membranes (MAMs), denoted by white arrowheads in panels E-J, are greatly affected in taz-deficient hearts. E and G show representative cross-sections of cardiac muscle of 2-month-old (E) and 8-month-old (G) control mice, respectively. In 2-month-old taz-deficient mice, MAMs appear slightly enlarged (F); however, in older mice, differences in MAM size and morphology become more pronounced (H-J). Scale bars, 500 nm. In all panels, mitochondria are marked with letter M, and sarcomeres are marked with the letter S.

Copyright

This image is from Acehan D, J Biol Chem 2011 Jan 14;286(2):899-908 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167527

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm37(H1/tetO-RNAi:Tafazzin)Arte	gene trap ROSA 26, Philippe Soriano; targeted mutation 37, TaconicArtemis

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm37(H1/tetO-RNAi:Tafazzin)Arte/Gt(ROSA)26Sor^+	involves: 129S6/SvEvTac * C57BL/6J