Phenotype Image Detail

Image

Caption

Mitochondrial defects in skeletal muscle of Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte}/Gt(ROSA)26Sor⁺ (taz-deficient) mice. Representative cross-sectional micrographs of extensor digitorum longus (EDL) (A-C, E, and G-I) and soleus muscles (F) are shown. A, cross-section of EDL from a 2-month-old non-transgenic (NTG) mouse. Honeycomb-like formations, denoted by white arrowheads, are abundantly present in EDL of 2-month-old (B-E) and 8-month-old (I) taz-deficient mice. F, aggregated mitochondria in the soleus muscle of a 2-month-old taz-deficient mouse. G, H, and I are representative micrographs of mitophagy (black arrowheads) in EDL muscle of 2-month-old (G) and 8-month-old (I) taz-deficient mice. H shows a grossly abnormal mitochondrion (black arrowhead) surrounded by an autophagic vacuole filled with ubiquitinated material (ub). Scale bars, 500 nm. In all panels, mitochondria are marked with the letter M, and sarcomeres are marked with the letter S.

Copyright

This image is from Acehan D, J Biol Chem 2011 Jan 14;286(2):899-908 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167527

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm37(H1/tetO-RNAi:Tafazzin)Arte	gene trap ROSA 26, Philippe Soriano; targeted mutation 37, TaconicArtemis

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm37(H1/tetO-RNAi:Tafazzin)Arte/Gt(ROSA)26Sor^+	involves: 129S6/SvEvTac * C57BL/6J