Phenotype Image Detail

Image

Caption

Impaired cardiac function in 8-month-old Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte}/Gt(ROSA)26Sor⁺ (taz-deficient) mice. A, representative M-mode echocardiographic tracings of non-transgenic (NTG) and taz-deficient mice. Diastolic dimension is indicated by solid lines, and systolic dimension is indicated by dotted lines. Chamber dilation and thinning of the ventricular walls are evident in the taz-deficient mouse. B, representative short axis cardiac MRI of NTG and taz-deficient mice at end diastole (ED) and end systole (ES).

Copyright

This image is from Acehan D, J Biol Chem 2011 Jan 14;286(2):899-908 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167527

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm37(H1/tetO-RNAi:Tafazzin)Arte	gene trap ROSA 26, Philippe Soriano; targeted mutation 37, TaconicArtemis

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm37(H1/tetO-RNAi:Tafazzin)Arte/Gt(ROSA)26Sor^+	involves: 129S6/SvEvTac * C57BL/6J