Phenotype Image Detail

Image

Caption

Histological analysis of Atmin^tm1.1Jhh/Atmin^tm1.1Jhh (KO) embryos. (A) Sagittal sections of comparable levels of wild-type (WT) and KO littermates at E18.5. Note the absence of lung (arrow), hypoplastic thymus (arrowhead), compressed thorax, steep ascending aorta, and exencephaly in the KO embryo. This embryo also represents an isolated case of omphalocele. Scale bars = 2 mm. (B) Micrographs of comparable sagittal sections of WT and KO littermates at E12.5-16.5. Note the apparent caudal drop of the atrium relative to the ventricle in KO embryos compared to WT littermates where the atrium seems to be propped up by the developing left lung. Scale bars = 1 mm. (C) Micrographs of comparable transverse sections of E12.5 WT and KO littermates at the upper (top panels) and lower levels (bottom panels) of the thorax. Open arrowheads point to the oesophagus, the filled arrowhead and arrows point at the trachea and lungs respectively that are only present in the WT.

Copyright

This image is from Jurado S, PLoS Genet 2010;6(10):e1001170, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:167544

Associated Alleles

Symbol	Name
Atmin^tm1.1Jhh	ATM interactor; targeted mutation 1.1, Jorg Heierhorst

Associated Genotypes

Allelic Composition	Genetic Background
Atmin^tm1.1Jhh/Atmin^tm1.1Jhh	C57BL/6-Atmin^tm1.1Jhh