Phenotype Image Detail

Image

Caption

Representative images: A) Rpe65^tm1Tmr/Rpe65^tm1Tmr [B6.129-Rpe65^tm1Tmr/Boc] with white retinal spots and retinal degeneration at 3 months of age, B) Rpe65^tm1Tmr/Rpe65^tm1Tmr mice with more retinal white spots and retinal degeneration at 5 months of age, C) Rpe65^rd12/ Rpe65^rd12 [B6(A)-Rpe65^rd12/J] with more white retinal spots and retinal degeneration at 5 months of age and D) C57BL/6J control at 5 months of age using an in vivo bright field retinal imaging microscope equipped with image-guided OCT capabilities (Micron III; Phoenix Laboratories, Inc., Pleasanton, CA, USA). The green lines are the plane in which the B-scan to the bottom of the fundus images were taken in the same animal.

Copyright

Photo courtesy of Mouse Mutant Resource at The Jackson Laboratory. J:348118

Associated Alleles

Symbol	Name
Rpe65^rd12	retinal pigment epithelium 65; retinal degeneration 12
Rpe65^tm1Tmr	retinal pigment epithelium 65; targeted mutation 1, T Michael Redmond

Associated Genotypes

Allelic Composition	Genetic Background
Rpe65^rd12/Rpe65^rd12	B6(A)-Rpe65^rd12/J
Rpe65^tm1Tmr/Rpe65^tm1Tmr	B6.129-Rpe65^tm1Tmr/BocJ