Phenotype Image Detail

Image

Caption

A) Crb1^em2Boc/Crb1^em2Boc Jak3^m1J/Jak3^m1J (B6.Cg-Crb1^em2Boc Jak3^m1J/Boc) retinas with an early-onset multifocal depigmented retinal lesions (retinal neovascularization) at 4 weeks of age. B) B6.Cg-Crb1^em2Boc Jak3^m1J/Boc with leakage of dye in Fluorescein angiography (FA) at 4 weeks of age. C) AlleleSymbol(MGI:6259426|0)/Crb1^em2Boc mice on a DBA/2J background (D2.Cg-Crb1^em2Boc/Boc) with a normal retina at 6 weeks of age. D) D2.Cg-Crb1^em2Boc/Boc with no leakage of dye in FA at 4 weeks of age using an in vivo bright field retinal imaging microscope equipped with image-guided OCT capabilities. The green lines are the plane in which the B-scan to the left of the fundus images were taken in the same animal.

Copyright

Photo courtesy of Mouse Mutant Resource at The Jackson Laboratory. J:353326

Associated Alleles

Symbol	Name
Crb1^em2Boc	crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated mutation 2, Bo Chang
Jak3^m1J	Janus kinase 3; mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Crb1^em2Boc/Crb1^em2Boc	D2.Cg-Crb1^em2Boc/Boc
Crb1^em2Boc/Crb1^em2Boc Jak3^m1J/Jak3^m1J	B6.Cg-Crb1^em2Boc Jak3^m1J/Boc