Phenotype Image Detail

Image

Caption

Ap2s1^em1(IMPC)Tcp/Ap2s1^em1(IMPC)Tcp mutants are recovered at E7.5 but are much smaller than littermates. A rudimentary egg-cylinder has formed, but no morphological primitive streak or other hallmarks typical of gastrulation at E7.5 (i.e. node, headfolds) are present. RT-PCR indicates limited expression during development. Knock-in LacZ showed no staining during gastrulation stages (E6.5, E7.5, E8.5). Additional information at websites.umass.edu/jmager/Ap2s1

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Ap2s1^em1(IMPC)Tcp	adaptor-related protein complex 2, sigma 1 subunit; endonuclease-mediated mutation 1, The Centre for Phenogenomics

Associated Genotypes

Allelic Composition	Genetic Background
Ap2s1^em1(IMPC)Tcp/Ap2s1^em1(IMPC)Tcp	C57BL/6NCrl-Ap2s1^em1(IMPC)Tcp/Cmmr