Phenotype Image Detail

Image

Caption

Dctn6^em1(IMPC)J/Dctn6^em1(IMPC)J embryos cannot be recovered at E7.5 (0/29), nor are the excess resorption sites. Homozygous mutants are recovered at E3.5 in expected ratios and appear as normal blastocysts. Mutants fail to hatch from the zona with apparent cell death and failure to form a typical outgrowth colony (no trophectoderm, primitive endoderm, or epiblast). RT-PCR indicates expression in the oocyte and post-gastrulation with notable absence in 16-cell and blastocyst stages. Additional information at websites.umass.edu/jmager/Dctn6

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Dctn6^em1(IMPC)J	dynactin 6; endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Dctn6^em1(IMPC)J/Dctn6^em1(IMPC)J	C57BL/6NJ-Dctn6^em1(IMPC)J/J