Phenotype Image Detail

Image

Caption

Ska2^{tm1b(KOMP)Wtsi}/Ska2^{tm1b(KOMP)Wtsi} mutants are recovered in expected ratios at E7.5 but are much smaller than littermates. A rudimentary egg-cylinder has formed, but no morphological primitive streak or other hallmarks typical of gastrulation at E7.5 (i.e. node, headfolds) are present. RT-PCR indicates robust wide-spread expression. No knock-in LacZ reporter staining is observed in E6.5, E7.5 or E8.5 embryos (not shown). Additional information at websites.umass.edu/jmager/Ska2

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Ska2^tm1b(KOMP)Wtsi	spindle and kinetochore associated complex subunit 2; targeted mutation 1b, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Ska2^tm1b(KOMP)Wtsi/Ska2^tm1b(KOMP)Wtsi	B6N(Cg)-Ska2^tm1b(KOMP)Wtsi/J