Phenotype Image Detail

Image

Caption

Actr8^{tm1.1(KOMP)Vlcg}/Actr8^{tm1.1(KOMP)Vlcg} mutants are recovered in expected ratios at E7.5 but are much smaller than littermates. A rudimentary egg-cylinder has formed, but no morphological primitive streak or other hallmarks typical of gastrulation at E7.5 (i.e. node, headfolds) are present. RT-PCR indicates robust expression in most stages. Very weak knock-in LacZ reporter expression at E7.5 and E8.5. Additional information at websites.umass.edu/jmager/Actr8

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Actr8^tm1.1(KOMP)Vlcg	ARP8 actin-related protein 8; targeted mutation 1.1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Actr8^tm1.1(KOMP)Vlcg/Actr8^tm1.1(KOMP)Vlcg	B6N(Cg)-Actr8^tm1.1(KOMP)Vlcg/J