Phenotype Image Detail

Image

Caption

Pmpcb^{tm1b(EUCOMM)Hmgu}/Pmpcb^{tm1b(EUCOMM)Hmgu} embryos cannot be recovered at E7.5 (0/32), and there are excess resorption sites. Homozygous mutants are recovered at E3.5 and appear as normal blastocysts. Mutants hatch from the zona and form morphologically normal outgrowths with very compact inner cell mass colonies. RT-PCR indicates limited pre-implantantion expression. Knock-in LacZ shows weak expression in gastrulation stages. Additional information at websites.umass.edu/jmager/Pmpcb

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Pmpcb^tm1b(EUCOMM)Hmgu	peptidase (mitochondrial processing) beta; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH

Associated Genotypes

Allelic Composition	Genetic Background
Pmpcb^tm1b(EUCOMM)Hmgu/Pmpcb^tm1b(EUCOMM)Hmgu	C57BL/6N-Pmpcb^tm1b(EUCOMM)Hmgu/Bay