Phenotype Image Detail

Image

Caption

Orc6^em1(IMPC)J/Orc6^em1(IMPC)J embryos cannot be recovered at E7.5 (0/34), nor are there excess resorption sites. Homozygous mutants are recovered at E3.5 in expected ratios and appear as dying morula. Mutants fail to hatch from the zona with apparent cell death, never reaching a morphological blastocyst stage. RT-PCR indicates robust expression both pre-implantationand post-implantation stages examined. Additional information at websites.umass.edu/jmager/Orc6

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Orc6^em1(IMPC)J	origin recognition complex, subunit 6; endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Orc6^em1(IMPC)J/Orc6^em1(IMPC)J	C57BL/6NJ-Orc6^em1(IMPC)J/J