Phenotype Image Detail

Image

Caption

Mrps22^{tm1.1(KOMP)Vlcg}/Mrps22^{tm1.1(KOMP)Vlcg} are recovered at expected mendelian ratios at E7.5. Mutants show consistent phenotype including developmental delay (~E6.0 size), no morphological hallmarks of gastrulation and no Brachyury (T)-positive cells. Phospho-histoneH3 (PH3) shows many dividing cells despite the overall developmental delay. RT-PCR show largely ubiquitous expression. Knock-in lacZ reporter shows no staining during gastrulation stages (only E7.5 shown). Additional information at websites.umass.edu/jmager/Mrps22

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Mrps22^tm1.1(KOMP)Vlcg	mitochondrial ribosomal protein S22; targeted mutation 1.1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Mrps22^tm1.1(KOMP)Vlcg/Mrps22^tm1.1(KOMP)Vlcg	C57BL/6N-Mrps22^tm1.1(KOMP)Vlcg/JMmucd