Phenotype Image Detail

Image

Caption

Clpx^{tm1.1(KOMP)Vlcg}/Clpx^{tm1.1(KOMP)Vlcg} mutants are recovered in expected ratios at E7.5 but are much smaller than littermates. A rudimentary egg-cylinder has formed, but no morphological primitive streak or other hallmarks typical of gastrulation at E7.5 (i.e. node, headfolds) are present. RT-PCR indicates robust expression in most stages. Strong knock-in LacZ reporter expression at E6.5, E7.5 and E8.5. Additional information at websites.umass.edu/jmager/Clpx

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Clpx^tm1.1(KOMP)Vlcg	caseinolytic mitochondrial matrix peptidase chaperone subunit; targeted mutation 1.1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Clpx^tm1.1(KOMP)Vlcg/Clpx^tm1.1(KOMP)Vlcg	C57BL/6N-Clpx^tm1.1(KOMP)Vlcg/JMmucd