Phenotype Image Detail

Image

Caption

Mtpap^{tm1.1(KOMP)Vlcg}/Mtpap^{tm1.1(KOMP)Vlcg} mutants are recovered in expected ratios at E7.5 but are much smaller than littermates. A rudimentary egg-cylinder has formed, but no morphological primitive streak or other hallmarks typical of gastrulation at E7.5 (i.e. node, headfolds) are present. RT-PCR indicates robust expression in most stages. Weak knock-in LacZ reporter expression is evident at E6.5 and E8.5. Additional information at websites.umass.edu/jmager/Mtpap

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Mtpap^tm1.1(KOMP)Vlcg	mitochondrial poly(A) polymerase; targeted mutation 1.1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Mtpap^tm1.1(KOMP)Vlcg/Mtpap^tm1.1(KOMP)Vlcg	C57BL/6N-Mtpap^tm1.1(KOMP)Vlcg/MbpMmucd